Sentinel lymph node biopsy at the time of mastectomy does not increase the risk of lymphedema: implications for prophylactic surgery
Identifieur interne : 004921 ( Main/Exploration ); précédent : 004920; suivant : 004922Sentinel lymph node biopsy at the time of mastectomy does not increase the risk of lymphedema: implications for prophylactic surgery
Auteurs : Cynthia L. Miller [États-Unis] ; Michelle C. Specht [États-Unis] ; Melissa N. Skolny [États-Unis] ; Lauren S. Jammallo [États-Unis] ; Nora Horick [États-Unis] ; Jean O'Toole [États-Unis] ; Suzanne B. Coopey [États-Unis] ; Kevin Hughes [États-Unis] ; Michele Gadd [États-Unis] ; Barbara L. Smith [États-Unis] ; Alphonse G. Taghian [États-Unis]Source :
- Breast cancer research and treatment [ 0167-6806 ] ; 2012.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Aisselle (), Analyse multivariée, Biopsie de noeud lymphatique sentinelle (effets indésirables), Bras (anatomopathologie), Facteurs de risque, Femelle, Humains, Indice de masse corporelle, Jeune adulte, Lymphadénectomie (effets indésirables), Lymphoedème (), Lymphoedème (étiologie), Mastectomie, Médecine préventive (), Période postopératoire, Sujet âgé, Tumeurs du sein (), Études prospectives.
- MESH :
- anatomopathologie : Bras.
- effets indésirables : Biopsie de noeud lymphatique sentinelle, Lymphadénectomie.
- étiologie : Lymphoedème.
- Pascal (Inist)
- Adulte, Adulte d'âge moyen, Aisselle, Analyse multivariée, Facteurs de risque, Femelle, Ganglion sentinelle, Biopsie, Anatomopathologie, Humains, Indice de masse corporelle, Jeune adulte, Lymphoedème, Mastectomie, Facteur risque, Lymphoedème, Médecine préventive, Prévention, Chirurgie, Cancer du sein, Bilatéral, Bras, Période postopératoire, Sujet âgé, Traitement, Tumeurs du sein, Études prospectives.
- Wicri :
- topic : Chirurgie.
English descriptors
- KwdEn :
- Adult, Aged, Anatomic pathology, Arm, Arm (pathology), Axilla (surgery), Bilateral, Biopsy, Body Mass Index, Breast Neoplasms (surgery), Breast cancer, Female, Humans, Lymph Node Excision (adverse effects), Lymphedema, Lymphedema (etiology), Lymphedema (therapy), Mastectomy, Middle Aged, Multivariate Analysis, Postoperative Period, Prevention, Preventive Medicine (methods), Prospective Studies, Risk Factors, Risk factor, Sentinel Lymph Node Biopsy (adverse effects), Sentinel lymph node, Surgery, Treatment, Young Adult.
- MESH :
- adverse effects : Lymph Node Excision, Sentinel Lymph Node Biopsy.
- etiology : Lymphedema.
- methods : Preventive Medicine.
- pathology : Arm.
- surgery : Axilla, Breast Neoplasms.
- therapy : Lymphedema.
- Adult, Aged, Body Mass Index, Female, Humans, Mastectomy, Middle Aged, Multivariate Analysis, Postoperative Period, Prospective Studies, Risk Factors, Young Adult.
Abstract
Women diagnosed with or at high risk for breast cancer increasingly choose prophylactic mastectomy. It is unknown if adding sentinel lymph node biopsy (SLNB) to prophylactic mastectomy increases the risk of lymphedema. We sought to determine the risk of lymphedema after mastectomy with and without nodal evaluation. 117 patients who underwent bilateral mastectomy were prospectively screened for lymphedema. Perometer arm measurements were used to calculate weight-adjusted arm volume change at each follow-up. Of 234 mastectomies performed, 15.8 % (37/234) had no axillary surgery, 63.7 % (149/234) had SLNB, and 20.5 % (48/234) had axillary lymph node dissection (ALND). 88.0 % (103/117) of patients completed the LEFT-BC questionnaire evaluating symptoms associated with lymphedema. Multivariate analysis was used to assess clinical characteristics associated with increased weight-adjusted arm volume and patient-reported lymphedema symptoms. SLNB at the time of mastectomy did not result in an increased mean weight-adjusted arm volume compared to mastectomy without axillary surgery (p = 0.76). Mastectomy with ALND was associated with a significantly greater mean weight-adjusted arm volume change compared to mastectomy with SLNB (p < 0.0001) and without axillary surgery (p = 0.0028). Patients who underwent mastectomy with ALND more commonly reported symptoms associated with lymphedema compared to those with SLNB or no axillary surgery (p < 0.0001). Patients who underwent mastectomy with SLNB or no axillary surgery reported similar lymphedema symptoms. Addition of SLNB to mastectomy is not associated with a significant increase in measured or self-reported lymphedema rates. Therefore, SLNB may be performed at the time of prophylactic mastectomy without an increased risk of lymphedema.
Url:
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: 000070
- to stream PascalFrancis, to step Curation: 000887
- to stream PascalFrancis, to step Checkpoint: 000077
- to stream Main, to step Merge: 004949
- to stream Pmc, to step Corpus: 003750
- to stream Pmc, to step Curation: 003749
- to stream Pmc, to step Checkpoint: 002707
- to stream PubMed, to step Corpus: 001F78
- to stream PubMed, to step Curation: 001F78
- to stream PubMed, to step Checkpoint: 001F78
- to stream Ncbi, to step Merge: 005087
- to stream Ncbi, to step Curation: 005087
- to stream Ncbi, to step Checkpoint: 005087
- to stream Main, to step Merge: 003E96
- to stream Main, to step Curation: 004921
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Sentinel lymph node biopsy at the time of mastectomy does not increase the risk of lymphedema: implications for prophylactic surgery</title><author><name sortKey="Miller, Cynthia L" sort="Miller, Cynthia L" uniqKey="Miller C" first="Cynthia L." last="Miller">Cynthia L. Miller</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Radiation Oncology, Massachusetts General Hospital</s1><s2>Boston, MA</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Specht, Michelle C" sort="Specht, Michelle C" uniqKey="Specht M" first="Michelle C." last="Specht">Michelle C. Specht</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Division of Surgical Oncology, Massachusetts General Hospital, 55 Fruit Street</s1><s2>Boston, MA 02114</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Skolny, Melissa N" sort="Skolny, Melissa N" uniqKey="Skolny M" first="Melissa N." last="Skolny">Melissa N. Skolny</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Radiation Oncology, Massachusetts General Hospital</s1><s2>Boston, MA</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Jammallo, Lauren S" sort="Jammallo, Lauren S" uniqKey="Jammallo L" first="Lauren S." last="Jammallo">Lauren S. Jammallo</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Radiation Oncology, Massachusetts General Hospital</s1><s2>Boston, MA</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Horick, Nora" sort="Horick, Nora" uniqKey="Horick N" first="Nora" last="Horick">Nora Horick</name><affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Department of Biostatistics, Massachusetts General Hospital</s1><s2>Boston, MA</s2><s3>USA</s3><sZ>5 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="O Toole, Jean" sort="O Toole, Jean" uniqKey="O Toole J" first="Jean" last="O'Toole">Jean O'Toole</name><affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Department of Physical and Occupational Therapy, Massachusetts General Hospital</s1><s2>Boston, MA</s2><s3>USA</s3><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Coopey, Suzanne B" sort="Coopey, Suzanne B" uniqKey="Coopey S" first="Suzanne B." last="Coopey">Suzanne B. Coopey</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Division of Surgical Oncology, Massachusetts General Hospital, 55 Fruit Street</s1><s2>Boston, MA 02114</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Hughes, Kevin" sort="Hughes, Kevin" uniqKey="Hughes K" first="Kevin" last="Hughes">Kevin Hughes</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Division of Surgical Oncology, Massachusetts General Hospital, 55 Fruit Street</s1><s2>Boston, MA 02114</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Gadd, Michele" sort="Gadd, Michele" uniqKey="Gadd M" first="Michele" last="Gadd">Michele Gadd</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Division of Surgical Oncology, Massachusetts General Hospital, 55 Fruit Street</s1><s2>Boston, MA 02114</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Smith, Barbara L" sort="Smith, Barbara L" uniqKey="Smith B" first="Barbara L." last="Smith">Barbara L. Smith</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Division of Surgical Oncology, Massachusetts General Hospital, 55 Fruit Street</s1><s2>Boston, MA 02114</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Taghian, Alphonse G" sort="Taghian, Alphonse G" uniqKey="Taghian A" first="Alphonse G." last="Taghian">Alphonse G. Taghian</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Radiation Oncology, Massachusetts General Hospital</s1><s2>Boston, MA</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">12-0379635</idno><date when="2012">2012</date><idno type="stanalyst">PASCAL 12-0379635 INIST</idno><idno type="RBID">Pascal:12-0379635</idno><idno type="wicri:Area/PascalFrancis/Corpus">000070</idno><idno type="wicri:Area/PascalFrancis/Curation">000887</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000077</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000077</idno><idno type="wicri:doubleKey">0167-6806:2012:Miller C:sentinel:lymph:node</idno><idno type="wicri:Area/Main/Merge">004949</idno><idno type="wicri:source">PMC</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3563357</idno><idno type="RBID">PMC:3563357</idno><idno type="wicri:Area/Pmc/Corpus">003750</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">003750</idno><idno type="wicri:Area/Pmc/Curation">003749</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">003749</idno><idno type="wicri:Area/Pmc/Checkpoint">002707</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002707</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">001F78</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001F78</idno><idno type="wicri:Area/PubMed/Curation">001F78</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001F78</idno><idno type="wicri:Area/PubMed/Checkpoint">001F78</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001F78</idno><idno type="wicri:Area/Ncbi/Merge">005087</idno><idno type="wicri:Area/Ncbi/Curation">005087</idno><idno type="wicri:Area/Ncbi/Checkpoint">005087</idno><idno type="wicri:doubleKey">0167-6806:2012:Miller C:sentinel:lymph:node</idno><idno type="wicri:Area/Main/Merge">003E96</idno><idno type="wicri:Area/Main/Curation">004921</idno><idno type="wicri:Area/Main/Exploration">004921</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Sentinel lymph node biopsy at the time of mastectomy does not increase the risk of lymphedema: implications for prophylactic surgery</title><author><name sortKey="Miller, Cynthia L" sort="Miller, Cynthia L" uniqKey="Miller C" first="Cynthia L." last="Miller">Cynthia L. Miller</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Radiation Oncology, Massachusetts General Hospital</s1><s2>Boston, MA</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Specht, Michelle C" sort="Specht, Michelle C" uniqKey="Specht M" first="Michelle C." last="Specht">Michelle C. Specht</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Division of Surgical Oncology, Massachusetts General Hospital, 55 Fruit Street</s1><s2>Boston, MA 02114</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Skolny, Melissa N" sort="Skolny, Melissa N" uniqKey="Skolny M" first="Melissa N." last="Skolny">Melissa N. Skolny</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Radiation Oncology, Massachusetts General Hospital</s1><s2>Boston, MA</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Jammallo, Lauren S" sort="Jammallo, Lauren S" uniqKey="Jammallo L" first="Lauren S." last="Jammallo">Lauren S. Jammallo</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Radiation Oncology, Massachusetts General Hospital</s1><s2>Boston, MA</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Horick, Nora" sort="Horick, Nora" uniqKey="Horick N" first="Nora" last="Horick">Nora Horick</name><affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Department of Biostatistics, Massachusetts General Hospital</s1><s2>Boston, MA</s2><s3>USA</s3><sZ>5 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="O Toole, Jean" sort="O Toole, Jean" uniqKey="O Toole J" first="Jean" last="O'Toole">Jean O'Toole</name><affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Department of Physical and Occupational Therapy, Massachusetts General Hospital</s1><s2>Boston, MA</s2><s3>USA</s3><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Coopey, Suzanne B" sort="Coopey, Suzanne B" uniqKey="Coopey S" first="Suzanne B." last="Coopey">Suzanne B. Coopey</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Division of Surgical Oncology, Massachusetts General Hospital, 55 Fruit Street</s1><s2>Boston, MA 02114</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Hughes, Kevin" sort="Hughes, Kevin" uniqKey="Hughes K" first="Kevin" last="Hughes">Kevin Hughes</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Division of Surgical Oncology, Massachusetts General Hospital, 55 Fruit Street</s1><s2>Boston, MA 02114</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Gadd, Michele" sort="Gadd, Michele" uniqKey="Gadd M" first="Michele" last="Gadd">Michele Gadd</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Division of Surgical Oncology, Massachusetts General Hospital, 55 Fruit Street</s1><s2>Boston, MA 02114</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Smith, Barbara L" sort="Smith, Barbara L" uniqKey="Smith B" first="Barbara L." last="Smith">Barbara L. Smith</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Division of Surgical Oncology, Massachusetts General Hospital, 55 Fruit Street</s1><s2>Boston, MA 02114</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Taghian, Alphonse G" sort="Taghian, Alphonse G" uniqKey="Taghian A" first="Alphonse G." last="Taghian">Alphonse G. Taghian</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Radiation Oncology, Massachusetts General Hospital</s1><s2>Boston, MA</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Breast cancer research and treatment</title><title level="j" type="abbreviated">Breast cancer res. treat.</title><idno type="ISSN">0167-6806</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Breast cancer research and treatment</title><title level="j" type="abbreviated">Breast cancer res. treat.</title><idno type="ISSN">0167-6806</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Anatomic pathology</term><term>Arm</term><term>Arm (pathology)</term><term>Axilla (surgery)</term><term>Bilateral</term><term>Biopsy</term><term>Body Mass Index</term><term>Breast Neoplasms (surgery)</term><term>Breast cancer</term><term>Female</term><term>Humans</term><term>Lymph Node Excision (adverse effects)</term><term>Lymphedema</term><term>Lymphedema (etiology)</term><term>Lymphedema (therapy)</term><term>Mastectomy</term><term>Middle Aged</term><term>Multivariate Analysis</term><term>Postoperative Period</term><term>Prevention</term><term>Preventive Medicine (methods)</term><term>Prospective Studies</term><term>Risk Factors</term><term>Risk factor</term><term>Sentinel Lymph Node Biopsy (adverse effects)</term><term>Sentinel lymph node</term><term>Surgery</term><term>Treatment</term><term>Young Adult</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Aisselle ()</term><term>Analyse multivariée</term><term>Biopsie de noeud lymphatique sentinelle (effets indésirables)</term><term>Bras (anatomopathologie)</term><term>Facteurs de risque</term><term>Femelle</term><term>Humains</term><term>Indice de masse corporelle</term><term>Jeune adulte</term><term>Lymphadénectomie (effets indésirables)</term><term>Lymphoedème ()</term><term>Lymphoedème (étiologie)</term><term>Mastectomie</term><term>Médecine préventive ()</term><term>Période postopératoire</term><term>Sujet âgé</term><term>Tumeurs du sein ()</term><term>Études prospectives</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Lymph Node Excision</term><term>Sentinel Lymph Node Biopsy</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Bras</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Biopsie de noeud lymphatique sentinelle</term><term>Lymphadénectomie</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Preventive Medicine</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Arm</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Axilla</term><term>Breast Neoplasms</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Lymphoedème</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Body Mass Index</term><term>Female</term><term>Humans</term><term>Mastectomy</term><term>Middle Aged</term><term>Multivariate Analysis</term><term>Postoperative Period</term><term>Prospective Studies</term><term>Risk Factors</term><term>Young Adult</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Aisselle</term><term>Analyse multivariée</term><term>Facteurs de risque</term><term>Femelle</term><term>Ganglion sentinelle</term><term>Biopsie</term><term>Anatomopathologie</term><term>Humains</term><term>Indice de masse corporelle</term><term>Jeune adulte</term><term>Lymphoedème</term><term>Mastectomie</term><term>Facteur risque</term><term>Lymphoedème</term><term>Médecine préventive</term><term>Prévention</term><term>Chirurgie</term><term>Cancer du sein</term><term>Bilatéral</term><term>Bras</term><term>Période postopératoire</term><term>Sujet âgé</term><term>Traitement</term><term>Tumeurs du sein</term><term>Études prospectives</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Chirurgie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Women diagnosed with or at high risk for breast cancer increasingly choose prophylactic mastectomy. It is unknown if adding sentinel lymph node biopsy (SLNB) to prophylactic mastectomy increases the risk of lymphedema. We sought to determine the risk of lymphedema after mastectomy with and without nodal evaluation. 117 patients who underwent bilateral mastectomy were prospectively screened for lymphedema. Perometer arm measurements were used to calculate weight-adjusted arm volume change at each follow-up. Of 234 mastectomies performed, 15.8 % (37/234) had no axillary surgery, 63.7 % (149/234) had SLNB, and 20.5 % (48/234) had axillary lymph node dissection (ALND). 88.0 % (103/117) of patients completed the LEFT-BC questionnaire evaluating symptoms associated with lymphedema. Multivariate analysis was used to assess clinical characteristics associated with increased weight-adjusted arm volume and patient-reported lymphedema symptoms. SLNB at the time of mastectomy did not result in an increased mean weight-adjusted arm volume compared to mastectomy without axillary surgery (p = 0.76). Mastectomy with ALND was associated with a significantly greater mean weight-adjusted arm volume change compared to mastectomy with SLNB (p < 0.0001) and without axillary surgery (p = 0.0028). Patients who underwent mastectomy with ALND more commonly reported symptoms associated with lymphedema compared to those with SLNB or no axillary surgery (p < 0.0001). Patients who underwent mastectomy with SLNB or no axillary surgery reported similar lymphedema symptoms. Addition of SLNB to mastectomy is not associated with a significant increase in measured or self-reported lymphedema rates. Therefore, SLNB may be performed at the time of prophylactic mastectomy without an increased risk of lymphedema.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Massachusetts</li></region></list><tree><country name="États-Unis"><region name="Massachusetts"><name sortKey="Miller, Cynthia L" sort="Miller, Cynthia L" uniqKey="Miller C" first="Cynthia L." last="Miller">Cynthia L. Miller</name></region><name sortKey="Coopey, Suzanne B" sort="Coopey, Suzanne B" uniqKey="Coopey S" first="Suzanne B." last="Coopey">Suzanne B. Coopey</name><name sortKey="Gadd, Michele" sort="Gadd, Michele" uniqKey="Gadd M" first="Michele" last="Gadd">Michele Gadd</name><name sortKey="Horick, Nora" sort="Horick, Nora" uniqKey="Horick N" first="Nora" last="Horick">Nora Horick</name><name sortKey="Hughes, Kevin" sort="Hughes, Kevin" uniqKey="Hughes K" first="Kevin" last="Hughes">Kevin Hughes</name><name sortKey="Jammallo, Lauren S" sort="Jammallo, Lauren S" uniqKey="Jammallo L" first="Lauren S." last="Jammallo">Lauren S. Jammallo</name><name sortKey="O Toole, Jean" sort="O Toole, Jean" uniqKey="O Toole J" first="Jean" last="O'Toole">Jean O'Toole</name><name sortKey="Skolny, Melissa N" sort="Skolny, Melissa N" uniqKey="Skolny M" first="Melissa N." last="Skolny">Melissa N. Skolny</name><name sortKey="Smith, Barbara L" sort="Smith, Barbara L" uniqKey="Smith B" first="Barbara L." last="Smith">Barbara L. Smith</name><name sortKey="Specht, Michelle C" sort="Specht, Michelle C" uniqKey="Specht M" first="Michelle C." last="Specht">Michelle C. Specht</name><name sortKey="Taghian, Alphonse G" sort="Taghian, Alphonse G" uniqKey="Taghian A" first="Alphonse G." last="Taghian">Alphonse G. Taghian</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 004921 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 004921 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= Pascal:12-0379635
|texte= Sentinel lymph node biopsy at the time of mastectomy does not increase the risk of lymphedema: implications for prophylactic surgery
}}
| This area was generated with Dilib version V0.6.31. |  |